https://x.com/rfsafe/status/1916052803400749549  The original S4–mitochondria framework was designed to explain why certain tissues show “macro‑damage” under non‑thermal RF/ELF exposure: cancer in heart and cranial nerve/glial tissues, male infertility via Leydig and germ cells, and autoimmune‑like dysregulation in immune cells. In all of those cases, the biology shares a common pattern: high density of voltage‑gated ion channels […]

In the original paper, non‑thermal radiofrequency (RF) and extremely low frequency (ELF) electromagnetic fields (EMFs) were proposed to act primarily via forced ion oscillations near voltage‑gated ion channels (VGICs), perturbing the S4 voltage sensor and thereby degrading the timing fidelity of ion fluxes. This S4/ion‑forced‑oscillation (S4/IFO) mechanism was linked to mitochondrial reactive oxygen species (ROS) […]

1.1 Conceptual Overview The original S4/ion‑forced‑oscillation and mitochondria model explains how non‑thermal electromagnetic fields create reactive oxygen species (ROS) and ion‑signalling noise on short timescales (milliseconds to hours). To explain why brief exposures can leave long‑lived or even transgenerational marks, we need a formal epigenetic layer. Epigenetic programming provides exactly that. It is a set […]

1. Multiple ROS “engines”, not just mitochondria Right now you treat mitochondria as the main ROS amplifier. The broader literature says that’s only half the story. There are at least three major ROS engines that EMFs can plausibly drive once ionic balance is disturbed: Mitochondrial ETC – what you already emphasize. NADPH oxidases (NOX/DUOX family) […]

1. Epigenetic Programming and Memory of EMF-Induced Perturbations 1.1 Conceptual Overview The original S4/IFO–mitochondria model explains how non‑thermal EMFs generate ROS and ion‑signalling noise on fast (ms–h) timescales. To explain why brief exposures can leave long‑lived or transgenerational marks, a formal epigenetic layer is needed. Epigenetic programming provides exactly this: a set of biochemical mechanisms […]

Circadian biology typically treats light—in the optical range—as the dominant time cue for the brain’s master clock in the suprachiasmatic nucleus (SCN). Blue light enters the eye, specialized cells signal to the SCN, and the core clock machinery adjusts its timing. A growing body of work suggests that this may not be the whole story. […]

The Herzification Hypothesis: How RF Is Rewriting Human Traits Across Generations The Herzification / Bioelectric Fidelity Hypothesis Why One Mechanism Explains Cancer, Infertility, Autism, ADHD, Collapsing Empathy, and the Transgenerational Erosion of Who We Are John Coates (@rfsafe) 22 November 2025 For 99.999 % of human evolution, the electromagnetic background was essentially zero. Then, in […]

A Root‑Cause Hypothesis for Non‑Native EMFs as Entropic Waste I didn’t start RF Safe as a business plan. I started it as a promise. In 1995, my firstborn daughter, Angel Leigh Coates, died from a catastrophic neural‑tube defect. At the time, the only actionable message I could find was folate, so I did what any […]

For roughly 99.999% of our evolutionary history, brains and bodies ran on a very quiet electromagnetic background. Cells talked to themselves with: Membrane voltages Voltage‑gated ion channels Calcium spikes Mitochondrial redox states Then, in about 150 years, we changed the electrical environment more than nature did in millions. 1880s: Heinrich Hertz’s spark‑gap experiments turn Maxwell’s equations […]

And I’m done watching the same suppression playbook run for the fourth decade in a row. November 22, 2025 John Coates (@rfsafe) Founder, RF SAFE (est. 1998) Inventor on multiple Li-Fi / photonics patents Former believer that “we can engineer our way out of this” I’m not here to scream “turn it all off.” I’m […]